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8

抑制剂 & 化合物

11

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T37839	20-hydroxy Prostaglandin E2 20-hydroxy Prostaglandin E2
	20-hydroxy Prostaglandin E2 (20-hydroxy PGE2) is a product of cytochrome P450 metabolism of PGE2 . ω-Oxidation at C-20 followed by β-oxidation and the loss of up to four carbons from the lower side chain is a prominent metabolic pathway for PGE2. 20-hydroxy PGE2 is the putative first intermediate in this chain of chemical transformations.
T37322	Steryl Glucosides
	Steryl glucosides are neutral glycolipids commonly found in plant cell membranes and vegetable oils that contain a glucose moiety conjugated to a sterol lipid. They function as glucose donors in the biosynthesis of glucocerebrosides in plant microsomes and are metabolic precursors to acylated/esterified steryl glucosides. Steryl glucosides are the major component of filter- and engine-damaging precipitates formed during biodiesel production from transesterification of vegetable oils. This produ...
T37257	13,14-dihydro-15-keto Prostaglandin D1 13,14-dihydro-15-keto Prostaglandin D1
	Prostaglandin D1 (PGD1) is the theoretical D-series metabolite of dihomo-γ-linolenic acid (DGLA), but to date it has not been isolated as a natural product. It is an inhibitor of ADP-induced platelet aggregation in humans with an IC50 value of 320 ng/ml, about 1/10 as potent as PGD2. 13,14-dihydro-15-keto Prostaglandin D1 (13,14-dihydro-15-keto PGD1) is the theoretical metabolite of PGD1 via the 15-hydroxy PG dehydrogenase metabolic pathway. No biological studies for this compound have been repo...
T37716	Galactosylcerebrosides (hydroxy)
	Galactosylcerebrosides are glycosphingolipids that contain a galactose attached to a ceramide acylated with a hydroxy or non-hydroxy fatty acid. They are metabolic precursors to sulfatides , found primarily in nerve tissues, and are the main glycosphingolipids in the central nervous system. Galactosylcerebrosides are involved in a multitude of cellular processes including cell agglutination, cellular signaling in glycosynapses, cellular development, and activation of T cells. They accumulate in ...
T37717	Galactosylcerebrosides (non-hydroxy)
	Galactosylcerebrosides are glycosphingolipids that contain a galactose attached to a ceramide acylated with a hydroxy or non-hydroxy fatty acid. They are metabolic precursors to sulfatides , found primarily in nerve tissues, and are the main glycosphingolipids in the central nervous system. Galactosylcerebrosides are involved in a multitude of cellular processes including cell agglutination, cellular signaling in glycosynapses, cellular development, and activation of T cells. They accumulate in ...
T37631	tetranor-12(S)-HETE
	12(S)-HETE is a product of arachidonic acid metabolism through the 12-lipoxygenase pathway. It is primarily found in platelets, leukocytes, and to a lesser extent in smooth muscle cells. It enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix. tetranor-12(S)-HETE is the major β-oxidation product resulting from peroxisomal metabolism of 12(S)-HETE in numerous tissues, and Lewis lung carcinoma cells. No biological function has yet been determined for tetran...
T83765	Dendrogenin A DDA
	Dendrogenin A (DDA) 作为一种选择性肝X受体(LXR)调节剂(SLiM)、胆固醇环氧水解酶(ChEH; Ki = 120 nM)的抑制剂及胆固醇的活性代谢产物，通过DDA合成酶将5,6α-环氧胆固醇与组胺结合形成。DDA在非癌性人乳腺上皮细胞和上皮黑色素细胞中存在，但在多种乳腺癌细胞或黑色素瘤细胞中未发现，且在分离的人乳腺肿瘤组织中仅以低水平存在。它抑制22(R)-羟基胆固醇诱导的LXRβ和LXRα激活(分别以IC50 = 76和362 nM)，但也是LXR的部分激动剂，在B16/F10小鼠黑色素瘤细胞中增加Nur77、NOR-1、LC3-I和LC3-II的蛋白水平。DDA选择性调节LXRα和LXRβ，而非孕烯X受体(PXR)、芳香烃受体(AhR)、维生素D受体(VDR)、维甲酸X受体γ(RXRγ)、维甲酸受体α(RARα)、过氧化物酶体增殖物激活受体α(PPARα)、PPARγ、糖皮质激素受体、雄激素受体、雌激素受体α(ERα)及ERβ在2.5 µM下。此外，DDA在2.5和5 µM的浓度下增加B16/F10和SK-MEL-28癌细胞中LC3-II的蛋白水平，并在2...
T35524	(1S)-Calcitriol
	(1S)-Calcitriol (1α,25-Dihydroxy-3-epi-vitamin-D3) is a natural metabolite of 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3). (1S)-Calcitriol exhibits potent vitamin D receptor (VDR)-mediated actions such as inhibition of keratinocyte growth or suppression of parathyroid hormone secretion[1]. 3‐epi‐Calcitroic acid is an end product of (1S)-Calcitriol (1α,25-Dihydroxy-3-epi-vitamin-D3; 3‐epi‐1a,25(OH)2D3) metabolism by rat CYP24A1[1]. [1]. Steve Y Rhieu, et al. Metabolic stability of 3-epi-1α,25-dihydr...

化合物

20-hydroxy Prostaglandin E2

Cat.No: T37839

Synonym: 20-hydroxy Prostaglandin E2

Steryl Glucosides

Cat.No: T37322

13,14-dihydro-15-keto Prostaglandin D1

Cat.No: T37257

Synonym: 13,14-dihydro-15-keto Prostaglandin D1

Galactosylcerebrosides (hydroxy)

Cat.No: T37716

Galactosylcerebrosides (non-hydroxy)

Cat.No: T37717

tetranor-12(S)-HETE

Cat.No: T37631

Cat.No: T83765

Synonym: DDA

(1S)-Calcitriol

Cat.No: T35524

Cat. No.	Product Name	Target	Signaling Pathways
T1688	Pregnanediol 5Beta-Pregnane-3Alpha,20alpha-Diol,孕甾二醇,Pregnandiol,孕二醇	Estrogen/progestogen Receptor; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Pregnanediol (5Beta-Pregnane-3Alpha,20alpha-Diol) 是一种黄体酮的主要代谢物 (metabolite)，能够通过尿液排出。它提供了一种间接测定体内孕激素水平的方法。
T0529	Dulcite Galactitol,Dulcitol,Euonymit,NSC 1944,D-Galactitol,Melampyrit,半乳糖醇	Endogenous Metabolite	Metabolism
	Dulcite (D-Galactitol) 是一种具有微甜味的糖醇，其是半乳糖的代谢分解产物。
T5788	XYLOBIOSE	IL Receptor; TNF	Apoptosis; Immunology/Inflammation
	Xylobiose 是一种木糖单体的二糖，单体之间具有 β-1, 4 键。
T5268	D-Arabitol D-Lyxitol,D-阿拉伯糖醇	Others; Endogenous Metabolite	Metabolism; Others
	D-Arabitol (D-Lyxitol) 是一种在人体内的累积能够能会导致神经毒性的多元醇。
T6S1683	Demethoxycurcumin Curcumin II,去甲氧基姜黄素,Desmethoxycurcumin,脱甲氧姜黄,Monodemethoxycurcumin	Apoptosis; Antioxidant; Antibacterial; Autophagy	Apoptosis; Autophagy; Microbiology/Virology; oxidation-reduction
	Demethoxycurcumin (Desmethoxycurcumin) 是姜黄素的主要活性成分，有抗炎和抗癌作用。
T4734	Suberic acid Octanedioic acid,1,8-Octanedioic acid,辛二酸	Others; Endogenous Metabolite	Metabolism; Others
	Suberic acid (1,8-Octanedioic acid) 被发现和肉毒碱-甲酰基-丙氨酸转位酶缺乏(丙二醇-羧基酶缺乏症)有关。
T8274	3-Methyl-L-histidine	Endogenous Metabolite	Metabolism
	3-Methyl-L-histidine 是一种肉类尤其是鸡肉摄入和大豆制品摄入的生物标记。
T78471	α,α-Trehalose 6-phosphate potassium Tre6P potassium	Endogenous Metabolite	Metabolism
	α,α-Trehalose 6-phosphate (Tre6P) potassium 是一种α,α′-trehalose的6-磷酸衍生物及内源代谢物。在Tre6P磷酸酶 (T6PP) 的催化下，α,α-Trehalose 6-phosphate可被高效转化为α,α′-trehalose。
TN5530	Volkensiflavone Talbotaflavone	Others	Others
	Volkensiflavone (Talbotaflavone) 是一种天然产物，存在于黄芪和藤黄中。它具有植物代谢物的作用,是一种次生代谢产物。Volkensiflavone 是一种双类黄酮，属于羟黄酮和羟黄酮。Volkensiflavone 可以作为佐剂用于过表达外排泵的多药耐药金黄色葡萄球菌的抗生素治疗。
TN3779	De-O-methyllasiodiplodin	IL Receptor; TNF; ROS; Antifection	Apoptosis; Immunology/Inflammation; Microbiology/Virology
	De-O-methyllasiodiplodin exhibits radical scavenging, moderate antibacterial, and potential anti-inflammatory effects, it shows moderate suppression effects on induced NO production. De-O-methyllasiodiplodin effectively lowers the blood glucose level in d
T36563	(E)-Guggulsterone
	Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism.1They are also inherently cytotoxic, as physiological imbalance contributes to increased oxidative stress.2,3Bile acid-controlled signaling pathways are promising novel targets to treat such metabolic diseases as obesity, type II diabetes, hy...

天然产物

Cat.No: T1688

Synonym: 5Beta-Pregnane-3Alpha,20alpha-Diol,孕甾二醇,Pregnandiol,孕二醇

Target: Estrogen/progestogen Receptor, Endogenous Metabolite

Cat.No: T0529

Synonym: Galactitol,Dulcitol,Euonymit,NSC 1944,D-Galactitol,Melampyrit,半乳糖醇

Target: Endogenous Metabolite

Cat.No: T5788

Target: IL Receptor, TNF

Cat.No: T5268

Synonym: D-Lyxitol,D-阿拉伯糖醇

Target: Others, Endogenous Metabolite

Demethoxycurcumin

Cat.No: T6S1683

Synonym: Curcumin II,去甲氧基姜黄素,Desmethoxycurcumin,脱甲氧姜黄,Monodemethoxycurcumin

Target: Apoptosis, Antioxidant, Antibacterial, Autophagy

Cat.No: T4734

Synonym: Octanedioic acid,1,8-Octanedioic acid,辛二酸

Target: Others, Endogenous Metabolite

3-Methyl-L-histidine

Cat.No: T8274

Target: Endogenous Metabolite

α,α-Trehalose 6-phosphate potassium

Cat.No: T78471

Synonym: Tre6P potassium

Target: Endogenous Metabolite

Volkensiflavone

Cat.No: TN5530

Synonym: Talbotaflavone

Target: Others

De-O-methyllasiodiplodin

Cat.No: TN3779

Target: IL Receptor, TNF, ROS, Antifection

(E)-Guggulsterone

Cat.No: T36563

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